Figure 7.

Effects of FAP inhibition on hepatic inflammation in Mdr2−/− mice. (A–C), Livers of control and Mdr2−/− fibrotic mice (n = 5–10/group) treated with FAPi as in Figure 5 were assessed for numbers of CD68 and YM1 expressing macrophages in 10 random high-power fields per mouse. (D–J), Hepatic transcript levels related to macrophage activation, polarization, and MMP expression were determined by qPCR. Data in (B–J) are presented as means ± standard error of the means (SEMs). Statistical analysis was performed as detailed in Figure 1.