Figure 8.
IBD-associated SMPs. (A), The ICCs of consistent DMPs identified through meta-analyses of 4 EWAS14,17, 18, 19 by Joustra et al48 stratified by comparison (CD vs HC; UC vs HC; and IBD vs HC). Black dashed lines represent the classification boundaries introduced by Koo and Li,47 with blocks representing poor (ICC < 0.5), moderate (0.5 ≤ ICC < 0.75), good (0.75 ≤ ICC < 0.9), and excellent (0.9 ≥ ICC). (B), Jittered visualization of the IBD-associated DMPs as reported on by Adams et al18 and Ventham et al,17 as well as the CRP-independent probes reported on by Somineni et al (C).21 The percentage methylation is plotted on the y-axis and the time point on the x-axis. Dashed lines connect samples obtained from the same donor. The cross-bar visualization represents the mean and standard error of the mean.