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. 2023 Feb 13;14:1054665. doi: 10.3389/fendo.2023.1054665

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Copyright © 2023 Liu, Lu, Peng, Jia, Ruan, Shi, Shu, Li, Jin, Zhai, He, Lou and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Glucose metabolic homeostasis was impaired in the liver of vdra^-/- ;vdrb^-/- zebrafish. (A) Blood glucose levels of vdra^-/-;vdrb^-/- fish and control siblings in the fasted state and postprandial state at 100 dpf. (B–D). Quantitative real-time PCR showed glut2, gck and chrebp transcriptional levels in the liver of mutants and control siblings at 100 dpf; (E) Quantitative real-time PCR showed gluconeogenesis marker gene g6pca.1, g6pca.2 and pck1 transcriptional levels in the liver of the vdra ^-/-;vdrb^-/- fish and control siblings at 100dpf. (F) The liver glycogen levels in vdra ^-/-;vdrb ^-/- fish and control siblings at 100 dpf. (G, H). The liver lactic acid levels in vdra ^-/-;vdrb ^-/- fish and control siblings at 100 dpf. The bars with different letters indicated significant difference (p<0.05).