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. 2023 Feb 6;13:1062424. doi: 10.3389/fonc.2023.1062424

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Copyright © 2023 Jin, Huo, Fan, Wang, Scott, Pizzi, Yao, Shao, Ma, Da Silva, Yamashita, Yoshimura, Zhang, Wu, Wang, Song and Ajani

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Whole exome sequencing (WES) analyses in patient ascites IP-116 and GA082517-PDX-derived human and murine samples. (A) Copy number variation (CNV) profiling for human lineage IP-116, GA0825PDX-G1 tumor, H0825 cells, and H0825-PDX978 tumor, with gains in red and losses in blue. (B) CNV profiling for murine lineage M0825 cells, P0825 cells, and P0825-PDX984L tumor. (C) Genomic mutations identified in human lineage GA0825PDX-G1, H0825 cells, and H0825-PDX978-tumor. The middle panel shows genomic mutations by sample and by gene (column). The histogram on the right shows the number of alterations accumulated on 43 listed genes in each individual sample. (D) Genomic alterations identified in murine lineage M0825 cells, P0825 cells, and P0825-PDX984 tumor. (E) Missense mutation in the TP53 from GA0825PDX-G1. (F) Mutated region mapped on the 3D structure of TP53.