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. 2023 Feb 28;24:37. doi: 10.1186/s13059-023-02857-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Cell type-specific DMC result for PBL DNA methylation data between RA and normal individuals. a Examination of six methods in identifying csDMCs of B cells from Liu et. al [32]. The ten csDMCs were identified and validated in two independent cohorts [36]. b Venn diagram showing overlap of reported csDMCs in CD4 cell type from six methods. c Top six KEGG pathways enriched by CeDAR-M uniquely identified csDMCs in CD4, but not TCA and TOAST