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Overall survival (OS) according to the alkaline phosphatase (ALP) response. ‐‐ 1. ALP normalization to the reference values (35–105 U/L) during radium‐223 treatments. ‐‐ 2. ALP over reference value before and after radium‐223 treatment. – 3. ALP in reference values before and after treatment. ‐‐ 4. ALP increase over reference values during radium‐223 treatment.
