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Factors selection and correlation analysis based on peripheral-blood immune indices of severe irAEs. a The LASSO coefficient profiles of the candidate variables; b the optimal tuning λ in the LASSO analysis selected with tenfold cross-validation via minimum criteria; c the development of severe irAEs corresponds to change-CD4+ T cells, change-CD4+/CD8+ ratio and change-CD3+CD56+CD16+NKT-like cells; d the development of severe irAEs corresponds to age and hypertension
