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. 2023 Feb 28;15:41. doi: 10.1186/s13195-023-01160-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A Boxplots showing the 18-month change in Eτ VOI SUVR across the quadrants. The 18-month change in Eτ VOI SUVR was significantly different between subjects in Q2 (or Q1) and Q3. B Boxplots showing the 18-month change in AD_signature VOI SUVR across the quadrants. The 18-month change in AD_signature VOI SUVR was significantly different across the quadrants (Q1 > Q2 > Q3). C Boxplots showing the 18-month change in cortical thickness across the quadrants. The 18-month change in cortical thickness was significantly different across the quadrants (Q1 < Q2 < Q3). D Boxplot showing the 18-month change in MMSE across the quadrants. The 18-month change in MMSE was significantly different across quadrants (Q1 < Q2 < Q3). A total of 109 subjects from the treatment arm of the solanezumab trial were excluded from these analyses. Note: the N’s are different in the above boxplots for flortaucipir change, thickness, and MMSE due to the availability of the data