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. 2023 Feb 28;15:41. doi: 10.1186/s13195-023-01160-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A Scatter plot of Braak stage vs AD_signature VOI SUVR. The red dotted line represents the AD_signature positivity cutoff of 1.1059. The numbers at the top represent the number of subjects for each Braak stage. For example, for Braak VI, 24/24 indicates that of the 24 Braak VI subjects in this analysis, 24 had elevated AD_signature signals. B Scatter plot of Braak stage vs Eτ VOI SUVR. The red dotted line represents the Eτ VOI SUVR positivity cutoff of 1.1052. Amyloid positivity is defined by a CERAD score of moderate to frequent at autopsy