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. 2023 Feb 28;15:41. doi: 10.1186/s13195-023-01160-6

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — A The average SUVR surface map of Q3 (Eτ−/AD_signature−) subjects, showing a lack of elevated flortaucipir signal in the entire cortex. B The average SUVR surface map of Q2 (Eτ+/AD_signature–) subjects. There is an elevated flortaucipir signal primarily in the regions of Eτ VOI region with the exception of the left middle temporal gyrus. C The average SUVR surface map of Q1 (Eτ+/AD_signature+) subjects. Widespread elevation of flortaucipir signal across the entire cortex with the exception of postcentral, precentral, and paracentral gyri and anterior cingulate. D–F Surface maps showing the percentages of subjects that are tau positive for all FreeSurfer regions in Q3 (Eτ−/AD_signature−), Q2 (Eτ+/AD_signature–), and Q1 (Eτ+/AD_signature+), respectively