Table 4:
Summary statistics of demographic and biochemical variables in individuals from INCIPE-1 carrying and non-carrying the two CYP24A1 variants shown to be associated with nephrolithiasis.
| Variables | Carriers, n = 38 | Non-carriers, n = 77 | P-value |
|---|---|---|---|
| Age, years, mean (SD) | 61.2 (14.2) | 63.4 (13.3) | .414 |
| Sex, male, n (%) | 15 (39.5) | 28 (36.4) | .905 |
| Ca, mg/dL, mean (SD) | 2.2 (0.1) | 2.2 (0.13) | .805 |
| P, mg/dL, mean (SD) | 0.9 (0.2) | 0.9 (0.2) | .775 |
| PTH, pmol/L, median (IQR) | 3.5 (2.7, 4.7) | 3.9 (2.9, 5.0) | .287 |
| eGFR, mL/min/1.73 m2, mean (SD) | 85.4 (18.4) | 84.1 (16.2) | .691 |
| 1,25 (OH)2 vitamin D, pmol/L, mean (SD) | 94.9 (25.26) | 99.3 (30.6) | .449 |
| 25 (OH) vitamin D, nmol/L, median (IQR) | 34.1 (23.4, 49.4) | 42.3 (27.8, 57.8) | .043 |
| Ratio 1,25 (OH)2 vitamin D/25 OH vitamin D, median (IQR) | 2.9 (2.0, 4.2) | 2.36 (1.6, 3.3) | .043 |
| Nephrolithiasis, n (%) | 12 (31.6) | 23 (29.9) | 1.000 |
Carriers are the subjects carrying the two CYP24A1 variants (shown in Table 3). Serum samples were not available in two cases. Non-carriers are subjects without the two variants.Ca, calcium; P, phosphate; IQR, interquartile range.