TABLE 4.

Longitudinal neurological evaluation and SIRT2 plasma levels in ARBRE study

Patients	ELISA SIRT2 (ng/mL)	Global brain image assessment (cm3)	Medial orbitofrontal cortex brain image assessment (a.u.)b	Evaluation of CNS functioning (NPZ12)
Early-cART1_t0	1.875	818,930	0.447	−0.125
Early-cART2_t0	0.796	630,188	0.329	0.842
Early-cART3_t0	1.231	631,082	0.304	0.592
Early-cART4_t0	1.592	760,060	0.382	0.075
Early-cART5_t0	0.49	673,883	0.370	0.967
Early-cART6_t0	0.837	739,790	0.350	−0.200
Early-cART7_t0	0.969	793,197	0.460	0.367
Early-cART8_t0	2.996	697,289	0.401	0.000
Early-cART9_t0	0.912	703,614	0.382	0.575
Early-cART1_t48	1.814	833,048	0.424	−0.533
Early-cART2_t48	0.639	638,473	0.302	0.733
Early-cART3_t48	1.078	634,807	0.333	0.892
Early-cART4_t48	2.026	749,111	0.355	−0.233
Early-cART5_t48	0.319	657,125	0.368	1.158
Early-cART6_t48	0.119	751,895	0.334	−0.075
Early-cART7_t48	0.548	778,229	0.389	0.575
Early-cART8_t48	0.036	705,423	0.396	0.475
Early-cART9_t48	0.946	711,199	0.351	0.642
Later-cART1_t0	0.959	850,686	0.496	0.917
Later-cART2_t0	0.868	753,710	0.366	0.733
Later-cART3_t0	0.547	773,725	0.437	0.708
Later-cART4_t0	2.04	716,441	0.350	0.442
Later-cART5_t0	1.803	670,009	0.243	0.692
Later-cART6_t0	1.909	710,208	0.355	0.158
Later-cART7_t0	1.275	N.D.a	N.D.	N.D.
Later-cART8_t0	0.979	N.D.	N.D.	0.600
Later-cART9_t0	2.286	711,307	0.322	−0.117
Later-cART10_t0	2.272	N.D.	N.D.	0.217
Later-cART1_t48	1.111	830,125	0.430	1.408
Later-cART2_t48	1.635	762,894	0.322	0.917
Later-cART3_t48	1.187	N.D.	N.D.	0.617
Later-cART4_t48	1.844	713,595	0.332	1.300
Later-cART5_t48	1.836	664,881	0.234	0.833
Later-cART6_t48	2.692	708,699	0.289	−0.125
Later-cART7_t48	0.87	N.D.	N.D.	N.D.
Later-cART8_t48	0.736	N.D.	N.D.	0.992
Later-cART9_t48	2.703	N.D.	N.D.	N.D.
Later-cART10_t48	2.751	774,740	0.376	0.433

^aN.D., not determined.

^ba.u., arbitrary units.