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. 2023 Jan 16;14(1):e03399-22. doi: 10.1128/mbio.03399-22

FIG 1.

FIG 1

cRNA synthesis is inhibited in human cells lacking ANP32A/B. (A to C) Segment 4, vRNA (A), cRNA (B), or mRNA (C) accumulation over time in eHAP WT versus dKO cells following infection with PR8 (MOI = 3). The fold change was calculated versus input (0 hpi). n = 3 biological replicates, plotted as means ± the standard deviations (SD). Significance between WT and dKO cells was assessed at 2 hpi using an unpaired t test following log transformation. (D to F) Segment 6 vRNA (D), cRNA (E), or mRNA (F) accumulation over time in eHAP WT versus dKO cells after infection with PR8 (MOI = 3). The fold change was calculated versus mock-infected cells. n = 3 biological replicates, plotted as means ± the SD. Significance was assessed using multiple unpaired t tests following log transformation and corrected for multiple comparisons using the false discovery rate. ns, not significant; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.