Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 23;97(2):e01716-22. doi: 10.1128/jvi.01716-22

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.

PMC Copyright notice

FIG 7 — GII.4 Sydney_2012 noroviruses present minimal intra-variant antigenic variation. (A) A monoclonal antibody (MAb) library developed against a wild-type GII.4 Sydney_2012 virus (RockvilleD1/US/2012) indicates binding lost only by a subset of MAbs targeting antigenic site A. The heatmap indicates MAb-VLP binding as detected by ELISA, and represents the normalized OD405nm values. The columns denote wild-type and mutant VLPs. The OD405 nm were normalized to the cross-reactive MAb 30A11 (1.0) and the negative control (0). (B) Polyclonal sera responses from animals immunized with RockvilleD1/US/2012 VLPs. Normalized curves are shown from 1 mouse polyclonal serum as example. (C) The heatmap indicates the EC50 value from HBGA-blocking titers from the polyclonal sera from animals immunized with RoclvilleD1/US/2012 and MD2004-3/US/2004 (a wild-type Farmington_Hills_2002 virus) VLPs. The columns denote wild-type and mutant VLPs, and the rows show individual polyclonal sera.