FIG 1.

Efficacy of anle138b in RML prion-infected mice. (A) Structure of anle138b. (B) All-cause mortality for 5 placebo diet- and 7 anle138b-treated Tg(Gfap-luc) mice with wild-type Prnp genes. (C) Bioluminescence trajectories for the same animals. Thin lines indicate individual animal trajectories, thick lines and dots indicate means per week per treatment group, and shaded regions indicate 95% confidence intervals of the means. Animals were imaged approximately weekly through ~300 dpi; the two long-surviving treated animals were imaged again in two final sessions near the end of life.