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Effect of anle138b on endpoints in knock-in mice. (A to I) All-cause mortality (A to C), bioluminescence trajectories (D to F), and histology endpoints (G to I) in anle138b- versus placebo-treated animals of genotypes ki-3F4-WT (A, D, and G), ki-3F4-FFI (B, C, and H), and ki-3F4-CJD (C, F, and I). (J) Combined all-cause mortality curve ignoring genotype.
