Fig. 2. rMERS-CoVMA DUB-negative virus causes attenuated disease in hDPP4 KI mice.
Groups of 10 or 5 mice were infected intranasally with either rMERS-CoVMA (blue) (n = 10) or DUB-negative rMERS-CoVMA (red) (n = 10) virus at 104 PFU or DMEM (Mock—black) (n = 5). a Weight loss kinetics after virus challenge and b survival percentages were monitored for 14 days. For survival (b), a Kaplan–Meier survival plot was made and analyzed with a log-rank test. (****P < 0.0001). Source data are provided as a Source Data file.