Table 1.
Characteristics of the participants.
| Whole group | Normal | MCI | Dementia | |
|---|---|---|---|---|
| N | 65 | 25 | 33 | 7 |
| Age (years) | 69.1±7.2 | 69.5±6.7 | 67.6±6.8 | 74.7±8.7 |
| Sex (male) | 29 (44.6%) | 7 (28.0%) | 18 (54.5%) | 4 (57.1%) |
| Composite cognitive score | 0.1±0.6 | 0.6±0.3 | −0.1±0.4 | −0.7±0.6 |
| VRS | 2.0±1.3 | 1.7±1.2 | 2.1±1.3 | 2.7±1.6 |
| OEF (%) | 45.5±6.1 | 46.9±5.1 | 44.9±6.6 | 43.2±6.9 |
| Fazekas score | 1.6±0.8 | 1.4±0.7 | 1.6±0.7 | 2.0±1.0 |
| Education (years) | 16.2±3.2 | 16.2±2.6 | 15.6±3.6 | 18.6±2.0 |
| EtCO2 (mmHg) | 37.7±4.6 | 36.8±4.6 | 38.2±4.5 | 38.4±5.6 |
| N with CSF samples | 43 | 18 | 23 | 2 |
| Aβ42 (picograms/ml) | 1465±612 | 1595±451 | 1311±566 | 2059±1910 |
| Aβ40 (picograms/ml) | 12654±4266 | 13504±3204 | 11213±3352 | 21574±11080 |
| Aβ42 / Aβ40 | 0.116±0.030 | 0.120±0.026 | 0.117±0.032 | 0.084±0.046 |
| Total tau (picograms/ml) | 310±130 | 305±111 | 290±118 | 601±136 |
| p-tau (picograms/ml) | 43±20 | 42±15 | 40±18 | 94±1 |
MCI: mild cognitive impairment; VRS: vascular risk score; EtCO2: end-tidal carbon dioxide; OEF: oxygen extraction fraction, corrected for EtCO2; Aβ42: β-amyloid-42; Aβ40: β-amyloid-40; p-tau: phosphorylated tau.
Note: Unless otherwise specified, data are mean ± standard deviation. Data in parentheses are percentages.