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Modified sgRNA scaffold (esgRNA) reduces the editing efficiencies of iACBE4-NG at E. coli genomic target sites. (A) Analysis of on-target (violet) and self-target (red) editing activities at five E. coli genomic sites by iACBE-NG with native sgRNA scaffold starting with GTTTT. (B) On-target (violet) and self-target (red) editing outcomes at five E. coli genomic sites by iACBE-NG with modified sgRNA scaffold (esgRNA) starting with GCCCC.
