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ADAM17 inhibition in combination with single-dose IR reduces tumor growth in an orthotopic lung cancer model. Lung cancer lesions were generated by injecting luc-expressing A549 lung cancer cells via tail vein. Tumor growth was monitored via IVIS by sequential measurement of bioluminescent signal. A, Fold change in photon flux/s/cm2 after treatment start. B, Representative bioluminescent images of mice harboring luc-expressing A549 lung cancer lesions. *, P < 0.05.
