Fig. 7.

Co-loading of AZ and MPS to NVs ameliorates bacterial burden and inflammation-induced lung damage in a mouse lung infection model. (A) Animal protocol for evaluating the therapeutic effect of AZ-MPS-NVs in the lung infection. CFU of bacteria in blood (B) and in the lung (C). Leukocytes (D) and neutrophils (E) in BALF; (F) the lung permeability determined by total proteins in BALF. Cytokines in BALF (G) and in blood (H). Data presented as the mean ± SD, n = 3,4. *P < 0.05, **P < 0.01, and ***P < 0.001.