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. 2022 Oct 13;108(3):870–881. doi: 10.3324/haematol.2022.281180

Figure 1.

Figure 1.

Study design and aims. We tested if polygenic trait scores (PTS) developed in non-sickle cell disease (SCD) individuals associate with hematologic traits (HT) (Aim 1) and clinical outcomes (Aim 2) in SCD patients. We also tested if genetic variants associated with HT have different effect sizes when comparing non-SCD and SCD individuals (Aim 3). Finally, we performed genome-wide association studies (GWAS) to identify genetic variants associated with HT in SCD patients (Aim 4). HbF: fetal hemoglobin.