Figure 6. Canagliflozin therapy decreases oxidative stress in chronically ischemic myocardium.

A, Protein oxidation as measured by Oxyblot staining was decreased in canagliflozin‐treated pigs (n=8) compared with controls (n=7, 1 sample excluded owing to poor sample run on gel). Band densitometry of entire lane for each sample normalized to average value in control group. B, Expression of mitochondrial antioxidant SOD2 was significantly increased in canagliflozin‐treated pigs compared with controls. Upper and lower borders of box represent upper and lower quartiles, middle horizontal line represents median, upper and lower whiskers represent maximum and minimum values. *P<0.05. SOD2 indicates superoxide dismutase 2.