Table 3.
Event Rates (per 100 Person‐Years) and Adjusted Hazard Ratio Values for Mortality and Hospitalization Outcomes Each Sepsis Group to Patients Without Sepsis
| No sepsis (ref) | All sepsis | P value | ||||||
|---|---|---|---|---|---|---|---|---|
| No. with events | Person‐years | Event rate per 100 | No. with events | Person years | Event rate per 100 | Hazard ratio | ||
| (95% CI) | ||||||||
| Outcomes | N=1 449 821 | N=808 673 | ||||||
| Mortality | 167 493 | 3 701 524 | 4.52 | 220 428 | 1 694 527 | 13.01 | 1.27 (1.25–1.28) | <0.001 |
| All‐cause hospitalization* | 604 851 | 2 488 921 | 24.30 | 481 263 | 901 985 | 53.36 | 1.38 (1.37–1.39) | <0.001 |
| CVD hospitalization* | 261 245 | 3 250 160 | 8.04 | 267 829 | 1 314 742 | 20.37 | 1.43 (1.41–1.44) | <0.001 |
| Composite 1† | 661 469 | 2 488 921 | 26.58 | 538 228 | 901 985 | 59.67 | 1.35 (1.34–1.36) | <0.001 |
| Composite 2‡ | 360 403 | 3 250 160 | 11.09 | 377 514 | 1 314 742 | 28.71 | 1.37 (1.35–1.38) | <0.001 |
| No sepsis (ref) | Implicit sepsis only | |||||||
|---|---|---|---|---|---|---|---|---|
| Outcomes | N=1 449 821 | N=448 644 | ||||||
| Mortality | 167 493 | 3 701 524 | 4.52 | 135 616 | 935 100 | 14.50 | 1.23 (1.21–1.25) | <0.001 |
| All‐cause hospitalization* | 604 851 | 2 488 921 | 24.30 | 346 926 | 472 068 | 73.49 | 1.46 (1.44–1.47) | <0.001 |
| CVD hospitalization* | 261 245 | 3 250 160 | 8.04 | 294 021 | 697 599 | 42.15 | 1.54 (1.52–1.56) | <0.001 |
| Composite 1† | 661 469 | 2 488 921 | 26.58 | 314 406 | 427 068 | 73.62 | 1.40 (1.39–1.42) | <0.001 |
| Composite 2‡ | 360 403 | 3 250 160 | 11.09 | 230 492 | 697 599 | 33.04 | 1.43 (1.41–1.44) | <0.001 |
| No sepsis (ref) | Explicit sepsis only | |||||||
|---|---|---|---|---|---|---|---|---|
| Outcomes | N=1 449 821 | N=124 841 | ||||||
| Mortality | 167 493 | 3 701 524 | 4.52 | 20 448 | 294 409 | 6.95 | 1.31 (1.28–1.33) | <0.001 |
| All‐cause hospitalization* | 604 851 | 2 488 921 | 24.30 | 74 236 | 174 319 | 42.59 | 1.33 (1.31–1.34) | <0.001 |
| CVD hospitalization* | 261 245 | 3 250 160 | 8.04 | 50 370 | 248 370 | 20.28 | 1.37 (1.35–1.38) | <0.001 |
| Composite 1† | 661 469 | 2 488 921 | 26.58 | 69 652 | 174 319 | 39.96 | 1.30 (1.29–1.31) | <0.001 |
| Composite 2‡ | 360 403 | 3 250 160 | 11.09 | 39 636 | 248 370 | 15.96 | 1.33 (1.31–1.34) | <0.001 |
| No sepsis (ref) | Both sepsis types | |||||||
|---|---|---|---|---|---|---|---|---|
| Outcomes | N=1 449 821 | N=235 188 | ||||||
| Mortality | 167 493 | 3 701 524 | 4.52 | 64 364 | 465 018 | 13.84 | 1.22 (1.20–1.24) | <0.001 |
| All‐cause hospitalization* | 604 851 | 2 488 921 | 24.30 | 174 031 | 255 598 | 68.09 | 1.32 (1.30–1.33) | <0.001 |
| CVD hospitalization* | 261 245 | 3 250 160 | 8.04 | 142 808 | 368 772 | 38.73 | 1.26 (1.24–1.28) | <0.001 |
| Composite 1† | 661 469 | 2 488 921 | 26.58 | 154 170 | 255 598 | 60.32 | 1.33 (1.31–1.34) | <0.001 |
| Composite 2‡ | 360 403 | 3 250 160 | 11.09 | 107 386 | 368 772 | 29.12 | 1.28 (1.27–1.30) | <0.001 |
CVD indicates cardiovascular disease; and ref, reference group.
*
Death was considered as a competing risk when examining the risk of all‐cause or CVD rehospitalization.
†
Composite 1 includes death or all‐cause rehospitalization.
‡
Composite 2 includes death or CVD rehospitalization.