Table 2.
Major Adverse Cardiac Event and Its Individual Components Relative to Deferral Based on iFR and FFR
| MACE/component | iFR, n=473 | FFR, n=435 | iFR vs FFR | P value | |
|---|---|---|---|---|---|
| Unadjusted HR (95% CI) | Adjusted HR (95% CI) | ||||
| MACE | 18.6 (88) | 16.8 (73) | 1.13 (0.83–1.54) | 1.08 (0.79–1.48) | 0.63 |
| All‐cause death | 7.6 (36) | 6.7 (29) | 1.14 (0.70–1.86) | 1.14 (0.69–1.87) | 0.62 |
| Cardiovascular death | 1.9 (9) | 2.0 (9) | 0.92 (0.36–2.31) | 0.97 (0.38–2.49) | 0.94 |
| Noncardiovascular death | 5.7 (27) | 4.6 (20) | 1.24 (0.70–2.22) | 1.21 (0.67–2.20) | 0.52 |
| Nonfatal MI | 5.3 (25) | 5.5 (24) | 0.97 (0.55–1.69) | 0.93 (0.58–1.63) | 0.80 |
| Unplanned revascularization | 9.7 (46) | 9.2 (40) | 1.06 (0.70–1.62) | 1.03 (0.67–1.59) | 0.89 |
Values are % (n) unless indicated otherwise. FFR indicates fractional flow reserve; HR, hazard ratio; iFR, instantaneous wave‐free ratio; MACE, major adverse cardiac event; and MI, myocardial infarction.