Table 4.
Outcomes According to Clinical Presentation and Physiology‐Based Technique
| Outcome | SAP, n=611 | ACS, n=297 | SAP vs ACS unadjusted HR (95% CI) | P value | Interaction P value |
|---|---|---|---|---|---|
| MACE | 16.7 (102) | 19.9 (59) | 0.82 (0.60–1.13) | 0.23 | |
| iFR | 17.5 (57) | 21.1 (31) | 0.82 (0.53–1.27) | 0.99 | |
| FFR | 15.8 (45) | 18.7 (28) | 0.82 (0.51–1.31) | ||
| All‐cause death | 6.7 (41) | 8.1 (24) | 0.82 (0.49–1.36) | 0.44 | |
| iFR | 7.7 (25) | 7.5 (11) | 1.03 (0.51–2.10) | 0.34 | |
| FFR | 5.6 (16) | 8.7 (13) | 0.63 (0.30–1.30) | ||
| Cardiovascular death | 1.6 (10) | 2.7 (8) | 0.60 (0.24–1.52) | 0.28 | |
| iFR | 1.8 (6) | 2.0 (3) | 0.91 (0.23–3.63) | 0.41 | |
| FFR | 1.4 (4) | 3.3 (5) | 0.41 (0.11–1.52) | ||
| Noncardiovascular death | 5.1 (31) | 5.4 (16) | 0.93 (0.51–1.70) | 0.81 | |
| iFR | 5.8 (19) | 5.4 (8) | 1.08 (0.47–2.46) | 0.58 | |
| FFR | 4.2 (12) | 5.3 (8) | 0.76 (0.31–1.87) | ||
| Nonfatal MI | 5.2 (32) | 5.7 (17) | 0.91 (0.51–1.65) | 0.77 | |
| iFR | 5.2 (17) | 5.4 (8) | 0.96 (0.41–2.22) | 0.88 | |
| FFR | 5.3 (15) | 6.0 (9) | 0.88 (0.38–2.0) | ||
| Unplanned revascularization | 9.3 (57) | 9.8 (29) | 0.95 (0.61–1.49) | 0.84 | |
| iFR | 9.2 (30) | 10.9 (16) | 0.84 (0.46–1.54) | 0.56 | |
| FFR | 9.8 (27) | 8.7 (13) | 1.10 (0.57–2.13) |
Values are % (n) unless indicated otherwise. ACS indicates acute coronary syndrome; FFR, fractional flow reserve; HR, hazard ratio; iFR, instantaneous wave‐free ratio; MACE, major adverse cardiac event; MI, myocardial infarction; and SAP, stable angina pectoris.