Table 6.
Cox Regression Analysis for Clinical Outcomes in 667 Patients With HCM
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | P value | HR | 95% CI | P value |
| Age | 1.02 | 1.00–1.04 | 0.039 | 1.01 | 0.99–1.03 | 0.492 |
| Female sex | 3.71 | 2.22–6.19 | <0.001 | 2.77 | 1.54–4.97 | 0.001 |
| Hypertension | 1.55 | 0.93–2.58 | 0.095 | 1.01 | 0.56–1.83 | 0.974 |
| Diabetes | 1.94 | 1.05–3.58 | 0.035 | 1.88 | 0.93–3.79 | 0.080 |
| CKD | 3.95 | 1.69–9.24 | 0.002 | 2.66 | 0.95–7.41 | 0.062 |
| Atrial fibrillation | 3.53 | 2.13–5.83 | <0.001 | 2.11 | 1.09–4.11 | 0.028 |
| Obstructive type | 2.04 | 1.10–3.78 | 0.025 | 1.83 | 0.92–3.64 | 0.083 |
| LA volume index | 1.04 | 1.02–1.05 | <0.001 | 1.02 | 1.00–1.04 | 0.034 |
| E/e' | 1.07 | 1.03–1.11 | <0.001 | 1.04 | 1.00–1.07 | 0.069 |
| MR progression | 4.37 | 2.51–7.59 | <0.001 | 2.46 | 1.29–4.71 | 0.007 |
| MAC progression | 3.53 | 1.82–6.83 | <0.001 | 1.64 | 0.79–3.40 | 0.187 |
| MV prolapse | 1.00 | 0.14–7.30 | 0.999 | |||
CKD indicates chronic kidney disease; E/e', ratio of early diastolic mitral inflow velocity/early diastolic mitral annular tissue velocity; HCM, hypertrophic cardiomyopathy; HR, hazard ratio; LA, left atrial; MAC, mitral annular calcification; MR, mitral regurgitation; and MV, mitral valve.