TABLE 3.
Comparison of amino acid sequences of the His-1 motif
| Enzymea | His-1 motif | Reference |
|---|---|---|
| Deacetoxycepharosporin C synthase | PHYDLSTIT | 28 |
| Isopenicillin synthase | WHEDVSLIT | 3 |
| Lysyl hydroxylase | PHHDASTFT | 22 |
| Prolyl 4-hydroxylase α-subunit | PHFDFARKD | 8 |
| Ethylene-forming enzyme | AHTDYGLL | 6 |
| Plant TOME8 | QHTDIGFVT | 5 |
| Hyoscyamine 6β-hydroxylase | GHYDGNLIT | 17 |
| Proline 3-hydroxylase | PHRDFVELD | 21 |
| Proline 4-hydroxylase | WHQDYIFWA | This study |
a
Data are shown for deacetoxycepharosporin C synthase from Cepharosporium acremonium, isopenicillin N synthase from Penicillium chrysogenum, lysyl hydroxylase from chicks, prolyl 4-hydroxylase α-subunit from humans, ethylene-forming enzyme from Pseudomonas syringae pv. phaseolicola PK2, plant TOME8 from tomato, hyoscyamine 6β-hydroxylase from Hyoscyamus niger, proline 3-hydroxylase from Streptomyces sp. strain TH1, and proline 4-hydroxylase from Dactylosporangium sp. strain RH1. Completely conserved histidine (H) and aspartic acid (D) residues are indicated by boldface type.