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. 2023 Feb 28;21:46. doi: 10.1186/s12915-023-01540-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Dissection of the immune landscape in atherosclerosis with scRNA-seq. a Schematic of the overall study design. AC, atherosclerotic core; PA, adjacent portion. b t-SNE plots showing 44,120 immune cells from atherosclerosis lesions. ILC, Innate lymphoid cells. c Dot plot showing average expression of known markers in indicated immune cell types. d Boxplot showing cell purity for each cell type by ROGUE. e Line chart showing tissue prevalence for each cell type estimated by Ro/e score. f Dot plots showing differentially enriched pathways in the global cell type between AC and PA tissues