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. 2023 Feb 28;21:46. doi: 10.1186/s12915-023-01540-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Characterisation of a novel dysfunctional foam macrophage population. a Radar plot showing enrichment of GO term for TREM2-related top 30 genes in C5 and C6 macrophage populations. b Boxplots showing phenotypic scores of TREM2⁺ Mac and SPP1⁺ Mac. ****, P ≤ 0.0001. Wilcoxon rank sum test. c Boxplots showing infiltrating score of SPP1⁺ Mac in paired early (n = 32) and advanced (n = 32) lesions (left) and non-IPH (n = 16) and IPH (n = 27) lesions. non-IPH, non-intraplaque haemorrhage; IPH, intraplaque haemorrhage. ****, P ≤ 0.0001. Wilcoxon rank sum test. d Heatmap showing different blocks of DEGs along the pseudotime trajectory (left). Selected KEGG pathways related to corresponding DEGs in heatmap (right). e Scatter plot showing the specificity scores of regulons of SPP1⁺ Mac. The top 5 regulons are highlighted. f Heatmap showing potential ligands driving the phenotype of SPP1⁺ Mac. g Heatmap showing the selected ligand-receptor pairs between SPP1⁺ Mac and other cells in lesions. h Boxplots showing CSF1 expression levels in paired early (n = 32) and advanced (n = 32) lesions. ****, P ≤ 0.0001. Paired Student’s t test. i Scatter plot showing the Pearson correlation of the proportion of CSF1⁺ mast cells and SPP1⁺ Mac cells