Table 3.

Mixed-effects Weibull proportional hazard regression analysis for prediction of 90-day mortality

	Model A		Model B		Model C
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Diabetes	1.24 (1.14–1.38)	< 0.001	1.17 (1.06–1.30)	0.002	1.18 (1.06–1.31)	0.003
Age	1.06 (1.05–1.73)	< 0.001	1.06 (1.04–1.07)	< 0.001	1.06 (1.04–1.06)	< 0.001
Sex	0.97 (0.88–1.08)	0.582	0.92 (0.83–1.03)	0.155	0.94 (0.84–1.05)	0.268
SOFA Score	1.14 (1.13–1.16)	< 0.001	1.13 (1.11–1.15)	< 0.001	1.13 (1.11–1.15)	< 0.001
Frailty			1.82 (1.60–2.06)	< 0.001	1.69 (1.48–1.93)	< 0.001
Ischemic heart disease					1.06 (0.93–1.20)	0.387
Chronic kidney disease					1.33 (1.16–1.52)	< 0.001
Arterial hypertension					0.85 (0.76–0.95)	0.005
Pulmonary comorbidity					1.11 (0.99–1.27)	0.071
Chronic heart failure					1.09 (0.93–1.27)	0.296

HR hazard ratio, CI confidence interval, SOFA Sequential Organ Failure Assessment, Center as random effect and Diabetes as fixed effects