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. Author manuscript; available in PMC: 2024 Feb 7.
Published in final edited form as: Circ Heart Fail. 2023 Feb 7;16(2):e009768. doi: 10.1161/CIRCHEARTFAILURE.122.009768

Fig. 1. Characterization of PH Models.

Fig. 1.

PH was confirmed in both models by hemodynamic (A-B) and echocardiographic measurements, as PH rats showed higher RV wall thickness (C), and RV systolic function measured by TAPSE (D) and TAPSE/RVSP (E) were significantly reduced in PH rats. Both PH models showed reductions in stroke volume (F) which were significant only for CFD-PH rats. In addition, the CDF-PH model had lower TAPSE/RVSP (E) and more severe RV dysfunction (G) in comparison to SD-PH rats. CDF: Fischer rat model; E/A: ratio of the early (E) to late (A) RV filling velocities; PH: pulmonary hypertension; RV: right ventricle; RVEDP: right ventricle end-diastolic pressure; RVSP: right ventricle systolic pressure; RVWT: right ventricle wall thickness; SD: Sprague-Dawley rat model; TAPSE: tricuspid annular plane systolic excursion; TAPSE/RVSP: measure of RV-pulmonary artery coupling; TV: tricuspid valve. **p<0.01; ***p<0.001. SD: n=6–11 Control, 10–16 PH; CDF: n=10–12 Control, 9–16 PH. Two-way ANOVA followed by Tukey post hoc test.