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. 2023 Feb 15;14:1136574. doi: 10.3389/fphys.2023.1136574

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Copyright © 2023 Wang, Zhao, Bu, Liu, Li, Zhang, Zhang, Yuan, Wang, Guo and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LSD prevents the development of LV hypertrophy in TASK^−/− mice. (A) Representative M-mode echocardiogram images of each group of mice at 4 weeks, 8 weeks, and 12 weeks of age. Quantitative comparison of echocardiographic parameter changes in different groups, including LV Mass (B), LVAWd (C), LVPWd (D), LVESD (E), stroke volume (F), ejection fractions (G), fractional shortening (H), and E/A ratio (I). Statistical significance was analyzed by two-way ANOVA with Bonferroni’s multiple comparison test (n = 6 mice for each group, p < 0.05). The symbol * marks a comparison between TASK^+/+ and TASK^−/− mice on a normal diet, and Ф and # represent a comparison between NSD and LSD in TASK^+/+ and TASK^−/− mice respectively.