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. 2023 Feb 15;14:1136574. doi: 10.3389/fphys.2023.1136574

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Copyright © 2023 Wang, Zhao, Bu, Liu, Li, Zhang, Zhang, Yuan, Wang, Guo and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enrichment analysis of significantly changed metabolites. Heatmap visualization of 51 differential metabolites between the TASK^+/+ and TASK^−/− mice with a normal diet (A). Comparing TASK^−/− to TASK^+/+ mice, 22 of their metabolites were upregulated, while 29 were downregulated (Wilcoxon rank-sum test, FDR-corrected p < 0.05). A heatmap was generated using Pearson’s chi-squared test for distance measurement and the Ward test for the clustering algorithm. Colors on the heatmap indicate expression levels (red means high; blue means low). (B) The bubble plot displays metabolic pathway enrichment analysis of significantly changed metabolites from (A). The metabolic pathway was analyzed with MetaboAnalyst 5.0 using KEGG. A bubble’s size indicates its enrichment ratio. Colors indicate the significance of the annotated enrichment value based on a −log10 (adjusted p-value).