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. 2023 Feb 15;14:1136574. doi: 10.3389/fphys.2023.1136574

FIGURE 7.

FIGURE 7

Metabolites that were significantly altered in TASK−/− mice and prevented by sodium restriction. (A) Heat maps summarize the metabolites significantly regulated in TASK−/− mice compared to TASK+/+ mice, and which were reversed by the two-week LSD (n = 8 in each group, p < 0.05, one-way ANOVA with Fisher’s LSD test). A heatmap was generated using Pearson’s chi-squared test for distance measurement and the Ward test for the clustering algorithm. Colors on the heatmap indicate expression levels (red means high; blue means low). (B) The bubble plot displays metabolic pathway enrichment analysis of those significantly reverted metabolites in response to the LSD from (A). Box-and-whisker plots summarize the normalized values (C). The Box-and-whisker plots include a central box that shows the interquartile range and a median line inside the box. Normal diet TASK+/+ mice vs. normal diet TASK−/− mice vs. LSD TASK−/− mice, p < 0.05, one-way ANOVA with Fisher’s LSD test.