Table 1.
SNPs and log odds ratio estimates (weights) for the Alzheimer’s Disease Genetic Risk Score (AD-GRS)
| Marker Name | Chromosome | Closest gene | Effect Allele | Effect Estimate | Odds Ratio for AD |
|---|---|---|---|---|---|
| rs4844610 | 1 | CR1 | A | 0.157 | 1.17 |
| rs6733839 | 2 | BIN1 | T | 0.182 | 1.2 |
| rs10933431 | 2 | INPP5D | G | −0.094 | 0.91 |
| rs9271058 | 6 | HLA -DRB1 | A | 0.095 | 1.1 |
| rs75932628 | 6 | TREM2 | T | 0.732 | 2.08 |
| rs9473117 | 6 | CD2AP | C | 0.086 | 1.09 |
| rs114812713 | 6 | OARD1 | C | 0.278 | 1.32 |
| rs12539172 | 7 | NYAP1 | T | −0.083 | 0.92 |
| rs10808026 | 7 | EPHA1 | A | −0.105 | 0.9 |
| rs73223431 | 8 | PTK2B | T | 0.095 | 1.1 |
| rs9331896 | 8 | CLU | C | −0.128 | 0.88 |
| rs7920721 | 10 | ECHDC3 | G | 0.077 | 1.08 |
| rs3740688 | 11 | SPI1 | G | −0.083 | 0.92 |
| rs7933202 | 11 | MS4A2 | C | −0.117 | 0.89 |
| rs3851179 | 11 | PICALM | T | −0.128 | 0.88 |
| rs11218343 | 11 | SORL1 | C | −0.223 | 0.8 |
| rs17125924 | 14 | FERMT2 | G | 0.131 | 1.14 |
| rs12881735 | 14 | SLC24A4 | C | −0.083 | 0.92 |
| rs593742 | 15 | ADAM10 | G | −0.073 | 0.93 |
| rs7185636 | 16 | IQCK | C | −0.083 | 0.92 |
| rs62039712 | 16 | WWOX | A | 0.148 | 1.16 |
| rs138190086 | 17 | ACE | A | 0.262 | 1.3 |
| rs3752246 | 19 | ABCA7 | G | 0.140 | 1.15 |
| rs6024870 | 20 | CASS4 | A | −0.128 | 0.88 |
| rs2830500 | 21 | ADAMTS1 | A | −0.073 | 0.93 |