Table 2.

Association of AD Genetic Risk Score (GRS) and APOE ε4 allele with midlife cognition and brain MRI outcomes

Outcome (in SD unless noted otherwise)	AD-GRS without APOE (continuous score)	APOE ε4 allele (any vs none)
Cognition *	β (95% CI)	β (95% CI)
MoCA	−0.14 (−0.26, −0.02)	−0.05 (−0.14, 0.05)
Composite Score	−0.03 (−0.10, 0.05)	0.02 (−0.03, 0.07)
Brain Health**
Brain Age, years	2.35 (0.01, 4.69)	0.44 (−1.28, 2.17)
Total Brain Volume	0.04 (−0.08, 0.02)	0.05 (−0.04, 0.14)
Hippocampal Volume	−0.24 (−0.54, 0.06)	0.18 (−0.04, 0.39)
White Matter Hyperintensity Volume	0.35 (0.00, 0.71)	0.07 (−0.19, 0.32)

MoCA; Montreal Cognitive Assessment; SD: standard deviation

^*Models adjusted for age, sex, education, 10 principal components

^*Models additionally adjusted for intracranial volume and MRI assessment center