Table 2.

Pooled prevalence of relative adrenal insufficiency in non-critically patients with cirrhosis

Analysis	Pooled Prevalence (95% CI)
Overall	37% (33–42%)
By Child-Pugh Classification
Child-Pugh A	27% (16–38%)
Child-Pugh B	39% (28–50%)
Child-Pugh C	64% (58–71%)
By Type of ACTH Stimulation Test
SD-SST	34% (28–41%)
LD-SST	44% (36–52%)
By Diagnostic Threshold
Peak total cortisol < 18 μg/dL	29% (23–35%)
Delta total cortisol < 9 μg/dL	36% (28–45%)
Peak free cortisol < 1.2 μg/dL	12% (4–20%)
Salivary cortisol (composite)†	19% (13–25%)
By Illness Acuity
Stable outpatient	33% (21–45%)
Hospitalized, non-critically ill	38% (34–43%)

Abbreviations: ACTH, adrenocorticotropic hormone; SD-SST, standard-dose short synacthen test; LD-SST, low-dose short synacthen test.

^†Composite of baseline salivary cortisol < 0.2 μg/dL, peak salivary cortisol < 1.3 μg/dL, or delta salivary cortisol < 0.3 μg/dL.