Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
One dimensional energy landscape of class A GPCRs. Along the activation pathway different holo and apo inactive (R), intermediate (R’) and active (R*) receptor conformations exist. Each receptor state features specific ligand binding properties, indicated here with different geometries. Active receptors transmit the extracellular signal to downstream signaling proteins with ligand-dependent efficiencies, as indicated here with different size of the intracellular binding pocket.
