Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 15;14:1069348. doi: 10.3389/fphar.2023.1069348

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Li, Ma, Wang, Zhang, Liu, Liu, Huang, Zhu, Zhang, Yin, Xu, Ding, Liu, Shi and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

ARAP1 knockdown inhibits dimeric PKM2 expression, HIF-1α accumulation, fibrogenesis and aberrant glycolysis, while partly restore tetrameric PKM2 formation in diabetic mouse (A) The effect of AAV2/9-shARAP1 on ARAP1, HIF-1α, PKM2, LDHA, HK2, COL I, COL IV and FN protein expression in the isolated glomeruli lysates of mouse kidney tissues was examined by Western blot analysis. (B) Cross-linking detection of PKM2 in the isolated glomeruli lysates of mouse. In all panels, the data are representative of at least three independent experiments. Data are presented as the mean ± SD. *p < 0.05, **p < 0.01, NS, not significant.