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. 2023 Feb 15;14:1069348. doi: 10.3389/fphar.2023.1069348

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Copyright © 2023 Li, Ma, Wang, Zhang, Liu, Liu, Huang, Zhu, Zhang, Yin, Xu, Ding, Liu, Shi and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ARAP1 knockdown attenuates renal function and tissue injury in the kidneys of diabetic mouse (A) Blood glucose (mmol/L) and (B) body weight (g) was measured at the indicated weeks. (C) Urinary ACR at various time points (12, 15, 17 and 20 weeks of age). (D) Urinary Ngal at various time points (12, 15, 17 and 20 weeks of age). (E) Serum creatinine at 20 weeks of age. (F) Serum BUN at 20 weeks of age. (G) Representative images of HE, PAS and Masson staining (×400). Bar = 50 μm. Arrows indicate positive staining. In all panels, the data are representative of at least three independent experiments. Data are presented as the mean ± SD. *p < 0.05, **p < 0.01, NS, not significant.