FIGURE 2.

Bar chart of bin placement for the 25th SNP (i.e. G × E locus) in Step 1 over 5,000 simulations. RB-Weighted: Rank-based weighted hypothesis testing using with initial bin size B₀ in Step 1; SB-Weighted: Significance-based weighted hypothesis testing using $\tau =\left(0,B_0/25000,3B_0/25000,\dots ,1\right)$ as the p-value cutoffs in Step 1. Simulation parameters:$R_{G_{25}}^2=R_{G_{25}\times E}^2$, $R_E^2=0.005$, N = 2, 000, M = 25, 000. Panel A) n_G = 0 G-only SNPs; Panel B: n_G = 80 G-only SNPs with $R_G^2=0.01$.