FIGURE 3.

Estimated power and FWER as a function of the initial bin size B₀. 80 G-only effects are present with $R_G^2=0.01$. RB-Weighted: Rank-based weighted hypothesis testing using with initial bin size B₀ in Step 1; SB-Weighted: Significance-based weighted hypothesis testing using $\tau =\left(0,B_0/25000,3B_0/25000,\dots ,1\right)$ as the p-value cutoffs in Step 1. Bonferroni: Standard Bonferroni correction within bin or subset; simpleM: The simpleM procedure proposed by Gao et al. (2008) with C = 0.995. Results are averaged over 5000 simulations.