Table 3. Top Ten DMC Containing Genes.
Genes are categorized first by number of DMCs, then in alphabetical order. Statistical significance was determined by running a Wald Test in DSS, where data displayed have a p-value threshold set to FDR <0.001 (n= 3 per treatment, per sex).
| Top Ten DMC Containing Genes: RRBS | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F1 Female 10 ppb | F2 Female 10 ppb | F1 Female 245 ppb | F2 Female 245 ppb | ||||||||||||
| Gene Name | Number of DMCs | Mean Differential Methylation | SD | Gene Name | Number of DMCs | Mean Differential Methylation | SD | Gene Name | Number of DMCs | Mean Differential Methylation | SD | Gene Name | Number of DMCs | Mean Differential Methylation | SD |
| Lrp1 | 8 | 62.89 | 5.28 | Dok7 | 5 | −62.24 | 2.73 | Mad1l1 | 6 | 48.44 | 5.96 | Tmem116 | 5 | −55.60 | 7.31 |
| Nav2 | S | 68.59 | 7.53 | Eda | 4 | 47.12 | 0.10 | Nav2 | 4 | 69.01 | 8.64 | Slc43a2 | 3 | 55.32 | 0.85 |
| Dock9 | 4 | 70.26 | 10.16 | Fgf12 | 4 | −75.69 | 4.59 | Abcb10 | 2 | −59.89 | 2.22 | Cacna2d3 | 2 | 62.62 | 8.56 |
| St3gal3 | 4 | −66.09 | 7.30 | Sox5 | 4 | 76.07 | 5.24 | Dock9 | 2 | 72.59 | 15.58 | Dip2c | 2 | −68.37 | 7.87 |
| Tfr2 | 4 | −48.99 | 1.16 | Cacna1f | 3 | 47.52 | 5.61 | Gpx1 | 2 | 61.04 | 4.50 | Fam13c | 2 | 64.70 | 0.00 |
| Adgrg4 | 2 | −59.26 | 2.03 | Cdkl5 | 3 | 46.04 | 4.35 | Pde10a | 2 | 83.57 | 11.72 | Gipc3 | 2 | −61.91 | 0.73 |
| Afap1l2 | 2 | −66.62 | 0.19 | Entpd8 | 3 | 60.13 | 1.78 | Pelp1 | 2 | 71.91 | 7.09 | Igsf21 | 2 | −54.54 | 9.16 |
| Ak5 | 2 | −3.46 | 88.54 | Eya2 | 3 | 60.24 | 8.43 | Shroom3 | 2 | 60.72 | 0.00 | Kank1 | 2 | −2.66 | 71.40 |
| Cnksr2 | 2 | 76.22 | 0.62 | Srgap1 | 3 | −27.63 | 88.53 | Acacb | 1 | −67.30 | NA | Pik3c2g | 2 | −40.53 | 2.78 |
| Cpne8 | 2 | −77.88 | 0.20 | Ar | 2 | 45.33 | 1.44 | Acvr2b | 1 | 73.53 | NA | Slc7a5 | 2 | −69.36 | 6.40 |
| F1 Mate 10 ppb | F2 Male 10 ppb | F1 Male 245 ppb | F2 Male 245 ppb | ||||||||||||
| Gene Name | Number of DMCs | Mean Differential Methylation | SD | Gene Name | Number of DMCs | Mean Differential Methylation | SD | Gene Name | Number of DMCs | Mean Differential Methylation | SD | Gene Name | Number of DMCs | Mean Differential Methylation | SD |
| Tcf4 | 6 | 54.21 | 2.23 | Agxt | 2 | −60.46 | 5.95 | Acot7 | 6 | 57.15 | 2.33 | Katna1 | 4 | 73.97 | 8.40 |
| Rlbp1 | 4 | −68.24 | 4.62 | Btla | 2 | −76.68 | 0.00 | Tcf4 | 6 | 64.40 | 4.32 | Pou2f1 | 4 | 0.19 | 79.44 |
| Smarca2 | 4 | −73.41 | 3.83 | Clmn | 2 | 65.79 | 2.91 | Bicc1 | 4 | 56.25 | 2.37 | Abca4 | 3 | −80.70 | 1.48 |
| Atp8b4 | 3 | 48.99 | 5.33 | Pcdhb16 | 2 | 57.51 | 3.38 | Irag1 | 4 | 70.52 | 1.69 | Ddx46 | 3 | −69.67 | 0.00 |
| Cdk7 | 3 | 51.65 | 2.05 | Sptb | 2 | −66.01 | 2.31 | Cdk7 | 3 | 50.44 | 0.68 | Ptpm2 | 3 | −22.65 | 67.25 |
| Gzmk | 3 | 56.50 | 6.98 | Acot7 | 1 | 69.40 | NA | Erc2 | 3 | 58.84 | 9.66 | Spidr | 2 | 63.63 | 1.33 |
| Pkd1l3 | 3 | 44.99 | 2.86 | Acox1 | 1 | −71.26 | NA | Pick1 | 3 | 61.41 | 9.90 | Zbtb12 | 2 | −51.57 | 2.22 |
| Slc27a4 | 3 | 66.19 | 8.23 | Adamts14 | 1 | 46.30 | NA | Rlbp1 | 3 | −64.19 | 0.13 | Ady | 1 | 69.99 | NA |
| Acp7 | 2 | 63.06 | 2.36 | Aff3 | 1 | −64.38 | NA | Scpep1 | 3 | 66.22 | 15.71 | Acot7 | 1 | 70.18 | NA |
| Adcy5 | 2 | 60.53 | 1.18 | AI314278 | 1 | 68.79 | NA | Atp8b4 | 2 | 49.51 | 2.14 | Actr2 | 1 | −59.52 | NA |