Table 2.
Associations of Clonal Hematopoiesis of Indeterminate Potential with 30% Decline in eGFR.
| CHIP | Number of participants | Number of eGFRs (IQR) | Median follow-up time, years (IQR) | Number of events | Incidence per 100 person-years | Unadjusted HR (95% CI) | Adjusted* HR (95%CI) | |
|---|---|---|---|---|---|---|---|---|
| ARIC | Yes | 584 | 3 (3,4) | 9 (8,22) | 143 | 2.20 | 1.23 (1.04,1.46) | 1.20 (1.01, 1.43) |
| No | 5,991 | 3 (3,4) | 9 (8,23) | 1,392 | 1.94 | reference | reference | |
| CHS | Yes | 240 | 3 (2,3) | 7 (3,7) | 40 | 2.14 | 1.48 (1.02, 2.13) | 1.38 (0.92, 2.06) |
| No | 1,461 | 3 (2,3) | 7 (4,7) | 216 | 1.53 | reference | reference | |
| MESA | Yes | 178 | 4 (4, 4) | 9 (9, 10) | 22 | 1.44 | 0.99 (0.64, 1.52) | 0.85 (0.55, 1.30) |
| No | 3,550 | 4 (4, 4) | 9 (9, 10) | 433 | 1.39 | reference | reference | |
| Meta-Analysis | Yes | 1,002 | 3 (3,4) | 8 (7, 14) | 205 | 2.05 | 1.24 (1.07, 1.43) | 1.17 (1.01, 1.36) |
| No | 11,002 | 3 (3,4) | 8 (7, 15) | 2,041 | 1.71 | reference | reference | |
| p = 0.004 | p = 0.036 |
ARIC = Atherosclerosis Risk in Communities Study; CHS = Cardiovascular Health Study; MESA = Multi-Ethnic Study of Atherosclerosis; CHIP = Clonal hematopoiesis of indeterminate potential; eGFR = estimated glomerular filtration rate.
*
Adjusted for age, age-squared, sex, baseline eGFR, diabetes, and log-urine albumin to creatinine ratio (where available at baseline).