Table 3.
Associations of Clonal Hematopoiesis of Indeterminate Potential with Longitudinal Change in eGFR.
| Cohort | CHIP | Number of participants | Number of eGFRs | Follow up time, years median (IQR) | Percent eGFR decline per year | Adjusted* difference (95% CI), %/year | Absolute eGFR decline per year | Adjusted* difference (95% CI), ml/min/1.73m2/year |
|---|---|---|---|---|---|---|---|---|
| ARIC | Yes | 584 | 3 (3,4) | 9 (8,22) | −2.30 (3.08) | −0.25 (−0.51, 0.01) | −1.87 (2.30) | −0.17 (−0.34, −0.01) |
| No | 5,991 | 3 (3,4) | 9 (8,23) | −2.02 (2.80) | reference | −1.69 (2.06) | reference | |
| CHS | Yes | 240 | 3 (2,3) | 7 (3,7) | −0.98 (4.60) | −0.13 (−0.60, 0.35) | −0.57 (2.67) | −0.09 (−0.39, 0.20) |
| No | 1,461 | 3 (2,3) | 7 (4,8) | −0.85 (3.89) | reference | −0.47 (2.29) | reference | |
| MESA | Yes | 178 | 4 (4, 4) | 9 (9, 10) | −1.60 (2.60) | 0.36 (−0.01, 0.74) | −1.03 (1.44) | 0.22 (0.01, 0.44) |
| No | 3,550 | 4 (4, 4) | 9 (9, 10) | −1.71 (2.44) | reference | −1.16 (1.49) | reference | |
| Meta-Analysis | Yes | 1,002 | 3 (3,4) | 9 (7, 16) | −1.75 (1.82) | −0.02 (−0.40, 0.36) | −1.14 (1.11) | −0.02 (−0.26, 0.23) |
| No | 11,002 | 3 (3,4) | 9 (8, 17) | −1.66 (1.66) | reference | −1.15 (1.07) | reference | |
| p = 0.934 | p = 0.906 |
ARIC = Atherosclerosis Risk in Communities Study; CHS = Cardiovascular Health Study; MESA = Multi-Ethnic Study of Atherosclerosis; CHIP = Clonal hematopoiesis of indeterminate potential; eGFR = estimated glomerular filtration rate.
*
Adjusted for age, age-squared, sex, baseline eGFR, diabetes, and log-urine albumin to creatinine ratio (where available at baseline).