Table 1:
Plasticity and stress-associated miRNAs in MDD pathogenesis
| miRNA biogenesis-associated enzymes | ||
|---|---|---|
| Name | Functions | References |
| Drosha, Dgcr8, Dicer, Trbp, Ago, and eIF2c | Primary (pri) and precursor (pre) miRNA processing, target identification, and loading | Ha et al. 2014; O’Brien et al. 2018; Davis and Hata 2009 |
| Plasticity-associated miRNAs | ||
| miRNAs | Affected Functions | Reference |
| miR-132-3p, miR-125b-5p, miR-138-5p, and miR-124-3p | Synaptic plasticity, spine morphogenesis, memory acquisition, fear conditioning, dendritic spine density | Wayman et al. 2008; Edbauer et al. 2010; Impey et al. 2010; Yi et al. 2014 |
| miR-134, pre-miR-134 | Dendritic spine formation, excitatory synaptic transmission; dendritic transportation; synaptic plasticity, LTP and memory formation; neuronal sprouting; dendritic spine density | Schratt et al. 2006; Gao et al. 2010; Bicker et al. 2013 |
| miR-138 | Palmitoylation mediated change in G protein α activity; synaptic plasticity; axonal regeneration | Siegel et al. 2009; Liu et al. 2013; Schroder et al. 2014 |
| miR-9, miR-125a/b and miR-188 | Synaptic plasticity, axonal elongation, synaptic connectivity; synaptic strength, and dendritic spine stabilization | Ye et al. 2016 |
| miR-124 | Synaptic plasticity, dendritic arborization, homeostatic synaptic plasticity, facilitation of sensory-motor neurons, 5HT-dependent long-term facilitation of sensory-motor neurons | Rajasethupathy et al. 2009; Hou et al. 2015; Roy et al. 2017 |
| let-7i, miR-19b, miR-29c, miR-101a, miR-124, miR-137, miR-153, miR-181a, miR-181c, miR-203, miR-218, miR-324-5p, miR-365, miR-409-5p, miR-582-5p, miR-155, miR-29a, miR-30e, miR-721, miR-699, miR-146a, miR-200c, miR-351, miR-155, miR-678, miR-764-5p, miR-135a* | Compromised HPA axis functionality, inflammation, synaptic plasticity, cell differentiation, cell survival, cell adhesion, and epigenetic modifications | Dwivedi et al. 2015 |
| miR-96, miR-141, miR-182, miR-183, miR-183*, miR-198, miR-200a, miR-200a*, miR-200b, miR-200b*, miR-200c, and miR-429 | Stress-induced depression phenotype in learned helpless rats | Smalheiser et al. 2011 |
| miR-298, miR-130b, miR-135a, miR-323, miR-503, miR-15b, miR-532, and miR-125a, miR-7a, miR-212, miR-124, miR-139, and miR-182 | Depression and response to antidepressants in the hippocampus | Cao et al. 2013 |
| Stress and MDD-associated miRNAs | ||
| miR-709, miR-186 | Stress-induced motor function impairments | Babenko et al. 2012 |
| miR-134, miR-17-5p and miR-124 | Dendritic spine morphology of neurons in the central nucleus of the amygdala | Schratt et al. 2006; Yu et al. 2008; Beveridge et al. 2009 |
| miR-34c | Anxiety-like behavioral changes in the amygdala of stress-induced mice | Haramati et al. 2011 |
| miR-16 | Maternal deprivation associated changes in mice hippocampus inducing anxiety-like phenotype | Bai et al. 2012 |
| let-7a | Anxiety-like behavioral changes in the amygdala of stress-induced mice | Bai et al. 2014 |
| miR-124 and miR-18a | Glucocorticoid receptor regulation under stress susceptibility | Vreugdenhil et al. 2009; Herman et al. 2012 |
| miR-504 | D1 and D2 dopamine receptor modulation in nucleus accumbens of adult rats due to maternally deprivation | Y. Zhang et al. 2013 |
| miR-135 | Regulates anxiety-like behavior by modulating the 5HT system | Issler et al. 2014 |
| miR-29c, miR-30a, miR-30c, miR-32, miR-193-5p, miR-204,miR-375, miR-5323p, and miR-698 | Transgenerational transmission of paternal lifetime experiences via sperm miRNAs | Rodgers et al. 2015 |
| miR-139-5p, miR-195, miR-320c and miR-34c-5p | Disrupting polyamine biosynthesis pathway in depressed suicide brains | Lopez et al. 2014a |
| miR-1202 | Metabotropic glutamate receptor modulation in brains of depressed suicide subjects | Lopez et al. 2014b |
| miR-218 | Depression susceptibility by increasing resiliency against stress-induced depression | Torres-Berrio et al. 2017 |
| miR-144-5p, miR-320a, miR-451a, miR-17-5p, miR-223-3p, miR-335, let-7a-5p, let-7d-5p, let-7f-5p, miR-24-3p, miR-425-3p, miR-330-3p, miR-345-5p, let-7b and let-7c | Widespread association of miRNAs with etiopathology of MDD in peripheral tissues of depressed patients | Dwivedi. 2016 |
| miR-16 | Modulates 5HT system in MDD and counter influences antidepressant fluoxetine response | Baudry et al. 2010 |
| miR-139-5p, miR-195, miR-320c and miR-34c-5p | Disrupt polyamine biosynthesis pathway in the brain of depressed suicide subjects | Lopez et al. 2014a |
| miR-215-5p, miR-192-5p, miR-202-5p, miR-19b-3p, miR-423-5p, miR-219a-2-3p; miR-511-5p, miR-483-5p | Involved in glutamatergic, ERK/MAPK, neuregulin, estrogen receptor, PI3K, telomeres signaling as well as axon guidance | Yoshino et al. 2020 |
| miR-301b-3p, - 132- 3p, - 132-5p, -449a- 5p, -30e-5p, - 338- 3p, - 144-3p, let-7 g- 3p, miR-200a-3p, miR-322-5p, miR-200b-3p, miR-20b-5p, miR-34b-5p, miR-34c- 3p, miR-34c-5p, miR-145-5p and miR-203a-3p | Involved in synaptic functions by modulating MAPK6, MMP19, and serotonergic signaling | Lauren et al, 2021a, 2021b, and 2021c |