Table 1.
Baseline characteristics and final diagnoses of enrolled patients.
| Total (n=277) | Lymphoma (n=75) | Tuberculosis adenitis (n=94) | Other malignancy (n=47) | Other diagnosis* (n=61) | |
|---|---|---|---|---|---|
|
| |||||
| Sex | |||||
| Males | 133 (48.0) | 45 (60.0) | 33 (35.1) | 27 (57.5) | 28 (45.9) |
| Females | 144 (52.0) | 30 (40.0) | 61 (64.9) | 20 (42.6) | 33 (54.1) |
| Age (median [IQR]) | 39.0 (29.4–49.5) | 41.8 (28.5–50.2) | 31.9 (26.9–40.0) | 58.3 (45.8–65.3) | 37.2 (30.3–49.1) |
| HIV status | |||||
| Positive | 120 (43.3) | 39 (52.0) | 50 (53.2) | 8 (17.0) | 23 (37.7) |
| Negative | 157 (56.7) | 36 (48.0) | 44 (46.8) | 39 (83.0) | 38 (62.3) |
| Performance Score (n=275) | |||||
| ECOG 0 | 140 (51.0) | 25 (33.8) | 56 (60.2) | 14 (29.8) | 45 (73.8) |
| ECOG 1 | 77 (28.0) | 25 (33.8) | 25 (26.9) | 18 (38.3) | 9 (14.8) |
| ECOG 2 | 24 (8.7) | 9 (12.2) | 6 (6.5) | 5 (10.6) | 4 (6.6) |
| ECOG 3 | 28 (10.2) | 13 (17.6) | 6 (6.5) | 7 (14.9) | 2 (3.3) |
| ECOG 4 | 6 (2.2) | 2 (2.7) | 0 | 3 (6.4) | 1 (1.6) |
| Patient Type | |||||
| Inpatient | 52 (18.8) | 22 (29.3) | 11 (11.7) | 12 (25.5) | 7 (11.5) |
| Outpatient | 225 (81.2) | 53 (70.7) | 83 (88.3) | 35 (74.5) | 54 (88.5) |
| Previous tuberculosis (n=275) | 64 (23.3) | 16 (21.3) | 28 (30.1) | 11 (23.9) | 9 (14.8) |
| On tuberculosis treatment | 39 (14.1) | 9 (12.0) | 23 (24.5) | 2 (4.3) | 5 (8.2) |
| Consistency of LN (n=273) | |||||
| Firm | 236 (86.5) | 73 (97.3) | 71 (77.2) | 41 (89.1) | 51 (85.0) |
| Fluctuant | 26 (9.5) | 0 | 15 (16.3) | 2 (4.4) | 9 (15.0) |
| Matted | 11 (4.0) | 2 (2.7) | 6 (6.5) | 3 (6.5) | 0 |
| Symptoms (n=275) | |||||
| Cough | 74 (26.9) | 22 (29.7) | 24 (25.8) | 19 (40.4) | 9 (14.8) |
| Weight loss | 133 (48.4) | 40 (54.1) | 53 (57.0) | 27 (57.5) | 13 (21.3) |
| Night sweats | 89 (32.7) | 34 (46.0) | 28 (30.4) | 13 (28.9) | 14 (23.0) |
| Location of lymph nodes | |||||
| Unilateral | 189 (68.2) | 38 (50.7) | 68 (72.3) | 36 (76.6) | 47 (77.1) |
| Bilateral | 88 (31.8) | 37 (49.3) | 26 (27.7) | 11 (23.4) | 14 (23.0) |
| Lymph node FNA/biopsy site | |||||
| Neck | 242 (87.4) | 59 (78.7) | 89 (94.7) | 42 (89.4) | 52 (85.3) |
| Axilla | 28 (10.1) | 14 (18.7) | 4 (4.3) | 3 (6.4) | 7 (11.5) |
| Inguinal | 7 (2.5) | 2 (2.7) | 1 (1.1) | 2 (4.3) | 2 (3.3) |
| Blood results (median [IQR]) | |||||
| LDH (units/L) (n=233) | 263 (216–333) | 303 (239–482) | 251 (191–299) | 268.5 (221.5–353.5) | 247 (215–306) |
| Hb (g/dL) (n=270) | 12.0 (9.6–13.4) | 10.6 (8.9–12.9) | 11.6 (9.6–12.7) | 12.9 (11.3–13.9) | 13.0 (11.6–13.9) |
| WCC (cells × 10^9) (n=271) | 7.3 (5.0–9.9) | 8.0 (4.9–11.6) | 6.2 (4.5–8.0) | 8.2 (5.7–10.1) | 8.0 (6.3–10.2) |
| Lymphocytes (cells × 10^9) (n=249) | 1.7 (1.0–2.3) | 1.5 (0.8–2.4) | 1.72 (0.9–2.1) | 1.9 (1.4–2.4) | 1.9 (1.4–3.1) |
Data are n/N; % (95% CI). ECOG = Eastern Cooperative Oncology Group.
Oncology Group. LN=Lymph node. LDH=Lactate dehydrogenase. Hb=Haemoglobin. WCC=White cell count. IQR=Interquartile range.
*
Other: reactive (n=15), salivary gland tumor (n=12), bacterial adenitis (n=5), sarcoidosis (n=4), lipoma (n=2), histoplasmosis (n=1), sinus histiocytosis (n=1), granulomatous inflammation unspecified (n=2), fibroadipose tissue (n=1), cyst (n=2), previous TB with scar tissue (n=1), fat necrosis (n=1), no diagnosis (n=14)