TABLE 3.

Adjusted hazards ratios for anticholinergic drug use on developing MCI^#

	Model 1		Model 2		Model 3
Variable	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Age	1.1 (1.1, 1.1)	<0.001	1.1 (1.1, 1.1)	<0.001	1.1 (1.1, 1.1)	<0.001
Female	1.2 (1.0, 1.5)	0.120	1.2 (1.0, 1.5)	0.115	1.2 (1.0, 1.5)	0.121
Education
< high school	Reference		Reference		Reference
= high school	0.8 (0.6, 1.0)	0.070	0.8 (0.6, 1.0)	0.067	0.8 (0.6, 1.0)	0.073
> high school	0.6 (0.4, 0.8)	0.001	0.6 (0.4, 0.8)	0.001	0.6 (0.4, 0.8)	0.001
Total number of prescription medications
<3	Reference		Reference		Reference
3-6	1.1 (0.8, 1.4)	0.608	1.1 (0.8, 1.4)	0.591	1.1 (0.8, 1.4)	0.659
>6	1.2 (0.9, 1.6)	0.274	1.2 (0.9, 1.7)	0.245	1.1 (0.8, 1.6)	0.469
Take any anticholinergic drug	1.4 (1.0, 1.8)	0.029
Total ACR score
0			Reference
1-3			1.4 (1.0, 1.8)	0.026
>3			1.3 (0.9, 1.8)	0.15
>3 versus 1-3 #			0.9 (0.7, 1.2)	0.687
Total number of anticholinergic drugs
0					Reference
1-2					1.3 (1.0, 1.8)	0.037
>2					1.5 (1.0, 2.1)	0.037
>2 versus 1-2 *					1.1 (0.8, 1.4)	0.508

Abbreviations: HR, hazard ratio; CI, confidence interval.

^#MCI was defined as clinical dementia rating (CDR) score =0.5.

^#is comparing total ACR score of >3 to 1-3 (the reference)

^*is comparing total number of anticholinergic drugs of >2 to 1-2 (the reference).

Models 1, 2, 3 used any anticholinergic drug use, total ACR score, total number of anticholinergic drugs as the main predictor, respectively.