TABLE 4.

Adjusted hazards ratios for anticholinergic drug use on developing dementia^#

	Model 4		Model 5		Model 6
Variable	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Age	1.1 (1.1, 1.2)	<0.001	1.1 (1.1, 1.2)	<0.001	1.1 (1.1, 1.2)	<0.001
Female	1.0 (0.7, 1.5)	0.799	1.0 (0.7, 1.5)	0.846	1.0 (0.7, 1.5)	0.812
Education
< high school	Reference		Reference		Reference
= high school	0.7 (0.4, 1.1)	0.126	0.7 (0.5, 1.1)	0.137	0.7 (0.5, 1.1)	0.130
> high school	0.6 (0.4, 1.0)	0.040	0.6 (0.4, 1.0)	0.042	0.6 (0.4, 1.0)	0.041
Total number of prescription medications
<3	Reference		Reference		Reference
3-6	0.9 (0.6, 1.4)	0.563	0.9 (0.6, 1.4)	0.524	0.9 (0.5, 1.4)	0.515
>6	0.9 (0.6, 1.6)	0.824	0.9 (0.5, 1.5)	0.647	0.9 (0.5, 1.6)	0.641
Take any anticholinergic drug	0.9 (0.6, 1.4)	0.641
Total ACR score
0			Reference
1-3			0.9 (0.5, 1.4)	0.516
>3			1.1 (0.6, 1.9)	0.825
>3 versus 1-3 #			1.2 (0.8, 1.9)	0.340
Total number of anticholinergic drugs
0					Reference
1-2					0.9 (0.6, 1.4)	0.573
>2					1.0 (0.6, 1.9)	0.915
>2 versus 1-2 *					1.2 (0.7, 1.9)	0.498

Abbreviations: HR, hazard ratio; CI, confidence interval.

^#Dementia was defined as clinical dementia rating (CDR) score ≥1.

^#is comparing total ACR score of >3 to 1-3 (the reference)

^*is comparing total number of anticholinergic drugs of >2 to 1-2 (the reference).

Models 4, 5, 6 used any anticholinergic drug use, total ACR score, total number of anticholinergic drugs as the main predictor, respectively.